Posted under Fertility Treatment by Dr. Suchetana Sengupta


6 Major Fertility Breakthroughs that have helped improve IVF outcomes

Assisted Reproductive Technology is a constantly evolving field with research focussing on improving the IVF outcomes.

In the last few decades, the world has witnessed many major fertility breakthroughs. Out of all, here is a list of top 6 major fertility breakthroughs so far:

1. Freezing eggs, sperms and Embryos

It was only in 1984 that the first birth was recorded from a frozen embryo. This breakthrough came decades after the first baby was conceived using frozen sperm. Just two years later, the first baby was born from a frozen egg. Frozen eggs, sperms, and embryos have become a standard option for treating fertility issues. Even women undergoing chemotherapy treatment can now preserve their healthy eggs.

Couples who are opting for IVF can also use frozen embryos for future use. Moreover, to help those unable to conceive, people can now donate eggs, sperm, and embryos.

2. Optimisation of IVF

In 1978, Louise Joy Brown, the first IVF baby was born, and since then millions of parents have undergone this procedure and welcomed their little bundle of joy. More improved technologies such as embryonic chromosomal screening and cell division monitoring along with patient oriented more refined hormonal injections and more minimally invasive procedures, use of Donor eggs, have improved the success rates of IVF.

Laser Assisted Hatching Techniques have been crucial for implantation success if frozen embryo Transfers cycles.

3. Pre Implantation Genetic Screening

Chromosomal screening can be now performed on embryos that are developed up to 5 days old. This offers a more extensive genetic analysis compared to the tests that were carried out earlier. The technique can improve the success rate of successful pregnancies as it helps in identifying healthy embryos and cut down the rates of miscarriage rates by half.

4. Personalised Embryo transfer via ERA (Endometrial receptivity Analysis)

Wrong timing of embryo transfer has been wound to be one of the reasons behind Implantation failure. Displacement in the window of implantation is seen on 3 out of 10 Transfers. In an IVF cycle the embryo has to be transferred either on day 3 or day 5, therefore the women’s endometrium preparation is synchronised such that it may be ready to receive the embryos at the time of Transfer. But if the endometrium was not receptive at the time of transfer, the embryo may fail to implant. In such Endometrial Receptivity Array can analyse the biopsied endometrial tissue and pinpoint the receptivity window specifically for that women enabling a PERSONALISED EMBRYO TRANSFER in the next cycle. This ground breaking tests has revolutionised IVF outcomes especially in cases of previous failed cycles.

5. Intra-cytoplasmic Sperm Injection

This was developed in the early 1990s. Through this process, a single sperm is injected directly into the egg. The process is most common for overcoming.

Male infertility issues like:

Female Infertility issues like:

  • Low sperm count and sperm abnormalities
  • Men with vasectomy
  • Men with Infections (HIV, Hepatitis)
  • Men with frozen sperms
  • Poor egg quality,
  • Low egg count
  • Previous fertilization failures via traditional IVF,
  • Previous IVF failures
  • Auto-immune problems

6. Freezing of Ovarian Tissue

This is relatively new. Freezing ovarian tissue involves removing, freezing and then re-implanting the tissue in women who are undergoing chemotherapy or radiation. This is for preserving fertility in future.

Best Fertility Treatment in Kolkata?

Having problems in conceiving? Planning for trying IVF? Looking for a clinic that offers the best fertility treatment in Kolkata? Contact Care IVF at 066-398-600. Visit:

About the author

The author, Dr. Suchetana Sengupta is a Fertility Consultant at Care IVF Kolkata. For an appointment with the doctor, call +91-33-66-398-600. You can also book a Skype Consultation here.


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